TERATOGEN SEBAGAI FAKTOR RISIKO PADA HIDROSEFALUS: SEBUAH TINJAUAN LITERATUR

I Kadek Okta Dharmadhyaksa, Ismi Uswatun Khasanah, Yuzi Putra Ananda, Shellyna Fidya Silka, Sri Kusrohmaniah, Augustina Sulastri

Abstract


Penelitian ini bertujuan untuk meninjau pengaruh teratogen terhadap hidrosefalus melalui studi literatur. Hidrosefalus merupakan kondisi neurologis serius yang disebabkan oleh akumulasi cairan serebrospinal di otak. Salah satu faktor risiko utama adalah paparan teratogen selama kehamilan. Metode dalam penelitian ini adalah tinjauan literatur dengan menggunakan 17 dari 51 studi yang membahas dampak teratogen dalam kehidupan sehari-hari. Teratogen yang dibahas meliputi alkohol (etanol), obat-obatan seperti misoprostol, infeksi virus dan bakteri seperti cytomegalovirus, serta paparan senyawa kimia seperti retinoid acid dan logam berat. Sumber literatur yang diambil sebagian besar adalah case-control study, retrospective study, case study, experimental, dan clinical report. Hasil tinjauan menunjukkan bahwa teratogen ini sangat mudah ditemui di dalam keseharian masyarakat Indonesia, terutama masyarakat yang hidup di daerah miskin atau di daerah sekitar tambang. Hasil ini bisa menjadi dasar dalam penyusunan intervensi lanjutan terhadap pola hidup sehat masyarakat, maupun dasar dalam pengkajian ulang kebijakan-kebijakan pemerintah yang berkaitan dengan lingkungan.


Keywords


Congenital disorders; Hydrocephalus; Pregnancy risks; Teratogen exposure

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References


Abebe, M. S., Seyoum, G., Emamu, B., & Teshome, D. (2022). Congenital hydrocephalus and associated risk factors: an institution-based case–control study, Dessie town, North East Ethiopia. Pediatric health, medicine and therapeutics, 175-182. https://doi.org/10.2147/PHMT.S364447

Afdhalurrahman, A. (2013). Gambaran neuroimaging hidrosefalus pada anak. Jurnal Kedokteran Syiah Kuala, 13(2), 117-122.

Al Zuhri, M., & Dona, F. (2021). Penggunaan Alkohol untuk Kepentingan Medis Tinjauan Istihsan. Journal of Law, Society, and Islamic Civilization, 9(1), 40-49. DOI:10.20961/jolsic.v9i1.51849

Anjani, I. A. T. (2018). Penolakkan sekolah pada anak dengan gangguan cemas sosial. Medicina, 49(3).

Bastow, B., & Isaacs, C. (2016). Teratology and drug use during pregnancy. Medscape. Recuperado de http://emedicine.medscape.com/article/260725-overview.

Benke, P. J. (1984). The isotretinoin teratogen syndrome. Jama, 251(24), 3267-3269.

Beuriat, P. A., Cattiaux, L., Guibaud, L., Szathmari, A., Sabatier, I., Rousselle, C., ... & Di Rocco, F. (2019). Isolated antenatal hydrocephalus after fetal exposure to misoprostol: teratogenic effect of the cytotec?. World Neurosurgery, 124, 98-100.

Centers for Disease Control and Prevention (CDC). (n.d.). Zika virus. Diakses dari https://www.cdc.gov/zika/about/index.html

Danielsson, B., Vargesson, N., & Danielsson, C. (2023). Teratogenicity and Reactive Oxygen Species after transient embryonic hypoxia: Experimental and clinical evidence with focus on drugs causing failed abortion in humans. Reproductive Toxicology, 122(June), 108488. https://doi.org/10.1016/j.reprotox.2023.108488

Del Bigio, M. R. (2001). Pathophysiologic consequences of hydrocephalus. Neurosurgery Clinics of North America, 12(4), 639-649.

Dewan MC, Rattani A, Mekary R, Glancz LJ, Yunusa I, Baticulon RE, Fieggen G, Wellons JC, Park KB, Warf BC (2018) Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis. J Neurosurg 1:1–15

Ernowo, E., & Oktaviani, P. (2010). Review Ofchromite Deposits Of Indonesia. Buletin Sumber Daya Geologi, 5(1), 1-10. https://doi.org/10.47599/bsdg.v5i1.250

Faccini, L. S., Friedrich, L., de Moura, S. K., Maria, F. D. S., & da Silva Inácio de Bone, S. (2022). Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection. ENeurologicalSci, 29(June). https://doi.org/10.1016/j.ensci.2022.100417

Fakhri, Y., Mahdavi, V., Ranaei, V., Pilevar, Z., Sarafraz, M., Mahmudiono, T., & Khaneghah, A. M. (2024). Ochratoxin A in coffee and coffee-based products: a global systematic review, meta-analysis, and probabilistic risk assessment. Reviews on Environmental Health, 39(2), 211-220. https://doi.org/10.1515/reveh-2022-0115

FAVO. (2024) Cytotec. Diakses dari https://favo.id/blogs/obat/cytotec

Hickman, T. T., Shuman, M. E., Johnson, T. A., Yang, F., Rice, R. R., Rice, I. M., ... & Johnson, M. D. (2017). Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. Journal of neurosurgery, 127(2), 240-248.

Honestdocs. (2019). Obat. Diakses dari https://www.honestdocs.id/obat

Kalyvas, A. V., Kalamatianos, T., Pantazi, M., Lianos, G. D., Stranjalis, G., & Alexiou, G. A. (2016). Maternal environmental risk factors for congenital hydrocephalus: a systematic review. Neurosurgical Focus FOC, 41(5), E3. https://doi.org/10.3171/2016.8.FOCUS16280

Kanat, A., Aydin, M. D., Sahin, B., Daltaban, I. S., Gel, M. S., Guvercin, A. R., & Demirtas, R. (2024). Important finding for COVID-19 pandemic: hydrocephalus-producing effect of Vaporized alcohol Disinfectant. Journal of Neurological Surgery Part A: Central European Neurosurgery, 85(04), 355-360.

Kementerian Energi dan Sumber Daya Mineral. (2012). Pencemaran Merkuri dari Darat ke Laut. Diakses dari https://www.minerba.esdm.go.id/berita/minerba/detil/20121013-pencemaran-merkuri-dari-darat-ke-laut

Kew, M. C. (2013). Aflatoxins as a cause of hepatocellular carcinoma. Journal of Gastrointestinal & Liver Diseases, 22(3).

Kubicsek, T., Kazy, Z., & Czeizel, A. E. (2011). Teratogenic potential of tribenoside, a drug for the treatment of haemorrhoids and varicose veins—a population-based case–control study. Reproductive Toxicology, 31(4), 464-469.

Lucignani, G., Guarnera, A., Rossi-Espagnet, M. C., Moltoni, G., Antonelli, A., Figà Talamanca, L., ... & Longo, D. (2022). From fetal to neonatal neuroimaging in TORCH infections: a pictorial review. Children, 9(8), 1210. https://doi.org/10.3390/children9081210

Madarina, A. (2022). Cyclophosphamide. Diakses dari https://hellosehat.com/obat-suplemen/cyclophosphamide/

MIMS Indonesia. (2024). Procto-Glyvenol. Diakses dari MIMS Indonesia https://www.mims.com/Philippines/drug/info/Procto-Glyvenol/Procto-Glyvenol

Murtagh, C., Wells, E., Raymond, E. G., Coeytaux, F., & Winikoff, B. (2018). Exploring the feasibility of obtaining mifepristone and misoprostol from the internet. Contraception, 97(4), 287-291. DOI: 10.1016/j.contraception.2017.09.016

Munch, T. N., Rasmussen, M. L. H., Wohlfahrt, J., Juhler, M., & Melbye, M. (2014). Risk factors for congenital hydrocephalus: a nationwide, register-based, cohort study. Journal of Neurology, Neurosurgery & Psychiatry, 85(11), 1253-1259.

Nugraha, W. C., Ishibashi, Y., & Arizono, K. (2023). Assessment of heavy metal distribution and contamination in the sediment of the Ciujung Watershed, Banten Province, Indonesia. Journal of Material Cycles and Waste Management, 25(5), 2619-2631. https://doi.org/10.1007/s10163-023-01661-4

Oliveira, R. J., Salles, M. J. S., Silva, A. F. da, Kanno, T. Y. N., Lourenço, A. C. dos S., Freiria, G. A., Matiazi, H. J., Ribeiro, L. R., & Mantovani, M. S. (2009). Effects of the polysaccharide β-glucan on clastogenicity and teratogenicity caused by acute exposure to cyclophosphamide in mice. Regulatory Toxicology and Pharmacology, 53(3), 164–173. https://doi.org/10.1016/j.yrtph.2008.12.007

Polanunu, N. F. A., Wahyuni, S., & Hamid, F. (2021). Seroprevalence and associated risk factors of Toxoplasma gondii infection among pregnant mother in Makassar, Indonesia. Plos one, 16(6), e0245572. https://doi.org/10.1371/journal.pone.0245572

Retmanasari, A., Widartono, B. S., Wijayanti, M. A., & Artama, W. T. (2017). Prevalence and risk factors for toxoplasmosis in Middle Java, Indonesia. EcoHealth, 14, 162-170. https://doi.org/10.1007/s10393-016-1198-5

Sakata-Haga, H., Sawada, K., Ohnishi, T., & Fukui, Y. (2004). Hydrocephalus following prenatal exposure to ethanol. Acta neuropathologica, 108, 393-398.

Savabieasfahani, M., Ahamadani, F. B., & Fadhel, B. T. (2024). Congenital anomalies in Baghdad children born near US military burn-pits: A case-control study showing tungsten and chromium association with increased odds of disease. Hygiene and Environmental Health Advances, 9(January), 100090. https://doi.org/10.1016/j.heha.2024.100090

Stern, R. S., Rosa, F., & Baum, C. (1984). Isotretinoin and pregnancy. Journal of the American Academy of Dermatology, 10(5), 851-854.

Tang, O. S., Gemzell-Danielsson, K., & Ho, P. C. (2007). Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects. International Journal of Gynecology & Obstetrics, 99, S160-S167.

Van Landingham, M., Nguyen, T. V., Roberts, A., Parent, A. D., & Zhang, J. (2009). Risk factors of congenital hydrocephalus: a 10 year retrospective study. Journal of Neurology, Neurosurgery & Psychiatry, 80(2), 213-217.

Varela, M. F., Miyabe, M. M., & Oria, M. (2020). Fetal brain damage in congenital hydrocephalus. Child's Nervous System, 36, 1661-1668.

Wangikar, P. B., Dwivedi, P., Sinha, N., Sharma, A. K., & Telang, A. G. (2005). Teratogenic effects in rabbits of simultaneous exposure to ochratoxin A and aflatoxin B1 with special reference to microscopic effects. Toxicology, 215(1–2), 37–47. https://doi.org/10.1016/j.tox.2005.06.022




DOI: http://dx.doi.org/10.22373/psikoislamedia.v9i2.26577

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Copyright (c) 2024 I Kadek Okta Dharmadhyaksa, Ismi Uswatun Khasanah, Yuzi Putra Ananda, Shellyna Fidya Silka, Sri Kusrohmaniah, Augustina Sulastri

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